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T1880 |
P7C3
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|
Others
|
|
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be... |
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T22043 |
BCATc Inhibitor 2
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|
Others
|
|
BCATc Inhibitor 2 exhibited an IC50 of 0.8 microM in the hBCATc assays; it is an active and selective inhibitor. BCATc Inhibitor 2 also blocked calcium influx into neuronal cells following inhibition of glutamate uptake,... |
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T8849 |
PF-9601N
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MAO
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PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD. |
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T11095L |
DREADD agonist 21
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|
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
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DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). |
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T9611 |
PF-04802367
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GSK-3
|
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PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ... |
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T6561 |
Laquinimod
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LAQ,ABR-215062 |
Apoptosis
,
Others
,
NF-κB
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|
Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy. |
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T9999 |
Sirtuin modulator 2
|
N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide |
Others
,
Sirtuin
|
|
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities. |
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T8055 |
TFEB activator 1
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(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612 |
Others
,
Autophagy
|
|
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease. |
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T77708 |
Casein kinase 1δ-IN-7
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|
Casein Kinase
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|
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease. |
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T77709 |
Casein kinase 1δ-IN-8
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|
Casein Kinase
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|
Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type. |
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T62568 |
IXA6
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IRE1
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IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's ... |
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T5447 |
Anle138b
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|
Beta Amyloid
,
Others
|
|
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease |
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T60295 |
Casein kinase 1δ-IN-1
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WAY-643895 |
Casein Kinase
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|
Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ. Casein kinase 1δ-IN-1 can be used in the study of neurodegenerative diseases such as Alzheimer's disease. |
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T61809 |
GSK-3β inhibitor 11
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GSK-3
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GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM. This compound demonstrates potential utility in the field of neurodegen... |
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T61439 |
DSS30
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|
Beta Amyloid
,
BACE
,
CDK
|
|
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and tr... |
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T16881L |
SIB 1553A
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|
AChR
|
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SIB 1553A is an orally available and selective agonist of nicotinic acetylcholine receptors (nAChRs), which are subtype-selective ligands for nicotinic acetylcholine receptors.SIB-1553A is a cognitive enhancer that may b... |
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T1993 |
J-147
|
J147 |
Epigenetic Reader Domain
,
Dopamine Receptor
,
Monoamine Oxidase
|
|
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... |
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T63321 |
20S Proteasome activator 1
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|
Proteasome
|
|
20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o... |
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T40766 |
1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid
|
|
|
|
1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid is a neuroactive compound utilized in neurodegenerative disease research. |
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T68950 |
Hepta-histidine
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|
|
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Hepta-histidine is a novel inhibitor of Tau aggregation against Tau-related neurodegenerative diseases including Alzheimer's disease (AD). |
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T61662 |
O-GlcNAcase-IN-4
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|
|
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O-GlcNAcase-IN-4 is an inhibitor of O-GlcNAcase. It holds potential for researching neurodegenerative diseases and disorders, including Alzheimer's disease [1]. |
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T30266 |
AZD8926
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AZD 8926,AZD-8926 |
|
|
AZD8926 is a potent and selective inhibitor of GSK3β(glycogen synthase kinase-3β). AZD8926 is potential for treating Alzheimer’s disease (AD), schizophrenia, and chronic as well as acute neurodegenerative diseases. |
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TP1362 |
Angiogenin (108-122)
|
Angiogenin 108-122 |
|
|
Angiogenin (108-122) is an angiogenin peptide. Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurod... |
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TP1320 |
Angiogenin (108-122) TFA (112173-49-6 free base)
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Angiogenin (108-122) TFA |
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Angiogenin (108-122) TFA is an angiogenin peptide.Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neu... |
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T77610 |
WAY-339495
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|
Others
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WAY-339495 may have anti-tumor, anti-inflammatory and analgesic activity and can be used to study obesity, cardiovascular disease, diabetes, neurodegenerative diseases, Alzheimer's disease and stroke. |
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T75751 |
β-Amyloid (1-40) (TFA)
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|
|
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β-Amyloid (1-40) TFA, a principal protein in plaques observed in the brains of Alzheimer's disease patients [1], is pivotal in research focused on this neurodegenerative disorder. |
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T79857 |
Risevistinel
|
NYX-783 |
iGluR
|
|
Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative conditions, including mild cognitive impairment, mild Alzheimer's ... |
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T79855 |
Nevadistinel
|
NYX-458,NYX-3054 |
iGluR
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Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, indicated for mitigating cognitive deficits related to neurodegenerative conditions, including mild cogniti... |
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T61128 |
C-ABL-IN-2
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|
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C-ABL-IN-2 is a highly effective inhibitor of the c-Abl protein, which plays a significant role in the development of several diseases, including cancer. This compound exhibits promise for investigating neurodegenerative... |
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T62534 |
POP-IN-2
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POP-IN-2 (Compound 7k) is a potent, covalently bound inhibitor of prolyl oligopeptidase (POP) (Ki: 6 nM).POP-IN-2 can be used in neurodegenerative disease and cancer research. |
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T74097 |
THX-B
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|
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THX-B, a potent non-peptidic antagonist of the neurotrophin receptor p75 (p75 NTR), is utilized in the study of diabetic kidney disease, neurodegenerative, and inflammatory disorders [1] [2] [3]. |
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TP2069 |
BDNF (human)
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|
|
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Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative ... |
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T80118 |
α-Synuclein (61-95) (human)
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|
|
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α-Synuclein (61-95) (human) constitutes the hydrophobic core of α-synuclein and is implicated in inducing neuronal cell death. This segment is utilized in the study of neurodegenerative conditions such as Alzheimer's dis... |
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T61546 |
C-ABL-IN-3
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|
|
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c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The ac... |
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T79010 |
Lp-PLA2-IN-12
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|
Phospholipase
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Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), and cardiovascular conditions... |
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T35804 |
C16 Lactosylceramide (d18:1/16:0)
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|
|
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C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Pla... |
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T60591 |
A2AAR antagonist 1
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|
|
|
A2AAR antagonist 1 (compound 21a) is an antagonist of A2AAR (adenosine A2A receptor) that shows high ligand efficiency with a Ki value of 20 nM. A2AAR antagonist 1 can be used in neurodegenerative disease research [1]. |
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T60824 |
Dyrk1A-IN-3
|
|
|
|
Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A). Dyrk1A-IN-3 has high binding affinity of DYRK1A with an IC 50 of 76 nM. Dyrk1A-IN-3 can be used in neur... |
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TP1673 |
β-Amyloid (11-22)
|
β-Amyloid 11-22 |
|
|
β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). A... |
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T81251 |
RTRD01
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|
|
|
rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269. This compound is capable of partially disrupting the interacti... |
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T79333 |
LZWL02003
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|
Reactive Oxygen Species
|
|
LZWL02003, an anti-neuroinflammatory agent, demonstrates a protective effect on MPP+-induced neuronal damage and reduces ROS expression. Additionally, it enhances cognition, memory, learning, and athleticism in Rotenone-... |
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T78833 |
AJH-836
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|
PKC
|
|
AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation of Munc13-1 from the cytoplasm to the plasma membrane. It is uti... |
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T79154 |
Casein kinase 1δ-IN-5
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|
Casein Kinase
|
|
Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in vitro, with potential applications in neurodegenerative dise... |
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T81820 |
Meso-Benzothiazole-BODIPY 505/515
|
|
|
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Meso-Benzothiazole-BODIPY 505/515, a boron dipyrromethene (BODIPY)-based fluorescent probe, is utilized in autophagy research, particularly for studying Alzheimer's disease, lysosomal storage disorders, and neurodegenera... |
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T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
|
|
|
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlate... |
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T62612 |
CD33 splicing modulator 1
|
|
|
|
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial cell activity. CD33 splicing modulator 1 has potential for the study of n... |
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T73289 |
MHTT-IN-1
|
|
|
|
mHTT-IN-1 (Example 1) is a potent inhibitor of the mutant huntingtin protein (mHTT), which is toxic and primarily responsible for Huntington's disease (HD), an inherited autosomal dominant neurodegenerative disorder. Thi... |
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T79716 |
C-ABL-IN-5
|
|
Bcr-Abl
|
|
C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier permeability, metabolic stability, and pharmacokinetic profiles. When labeled w... |
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T35594 |
Cuspin-1
|
|
|
|
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative dise... |
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T73683 |
AC-VEID-CHO TFA
|
|
|
|
AC-VEID-CHO (TFA) is a peptide-derived inhibitor targeting Caspases-6, -3, and -7, exhibiting IC50 values of 16.2 nM, 13.6 nM, and 162.1 nM, respectively. This compound demonstrates significant inhibitory potency and is ... |
